Moravske Toplice is located near all the most important road connections in this part of Slovenia. It can be reached via a motorway running between Ljubljana and Maribor, and on other roads from Austria and Hungary.

From Ljubljana and Maribor, Slovenia
Take the A1 motorway from Ljubljana towards Maribor and follow the signs for Murska Sobota, Lendava, and Budapest (A5 motorway). Leave the motorway at the Gančani–Moravske Toplice exit

From Vienna and Graz, Austria
You can take a slightly longer route via Maribor and follow the above directions, or you can leave the motorway between Graz and Maribor and turn towards Bad Radkersburg, just before Šentilj, and continue your drive towards Murska Sobota. You will then enter Slovenia near the village of Gederovci in the Prekmurje region. Follow the main road towards Murska Sobota, and then towards Moravske Toplice.

From Budapest, Hungary
Take the A7 motorway from Budapest to the junction near Letenye. At the Letenye junction, follow the M70 highway towards Ljubljana. You will enter Slovenia at the village of Pince. Follow the A5 highway towards Ljubljana until you get to the Moravske Toplice–Gančani exit, where you can leave the highway.

From Zagreb, Croatia
Take the A4 highway towards Budapest. At the Čakovec exit, follow the signs for Mursko Središče. You cross the Croatian-Slovenian border at the Mursko Središče border crossing.